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KMID : 0380020130280020106
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Korean Journal of Biotechnology and Bioengineering
2013 Volume.28 No. 2 p.106 ~ p.114
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Effect of Ponciri Fructus Extracts Fermented with Ganoderma lucidum on the Collagen Synthesis and Expression of Matrix Metalloproteinase-1
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Lee Gye-Won
Park Sung-Min
Yoo Yung-Choon
Cho Young-Ho
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Abstract
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Ponciri fructus, the unripe fruits of Poncirus trifoliata, are widely used in oriental traditional medicine as a remedy for inflammation, gastritis, emesis, digestive ulcers, allergy, and dysentery. To study the anti-wrinkle effects of Ponciri fructus extract (PFE) containing flavanone glycosides, PFE was fermented with Ganoderma lucidum mycelia and its biological activities were investigated. In Ponciri fructus extracts fermented with G. lucidum (G-PFE), polyphenol content was 1,021.00±0.50 μg/mL and flavonoid content was 589.41±0.21 μg/mL. G-PFE was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and superoxide anion radical by a dose dependent manner, respectively. G-PFE showed higher antioxidant activity than that of PFE. In addition, the photoprotective properties of G-PFE was tested in human dermal fibroblasts (HDF) exposed to UVA radiation. G-PFE inhibited the activity of matrix metalloproteinase-1 (MMP-1) and showed a dose dependent decrease in the expression level of MMP-1. G-PFE also increased collagen biosynthesis in HDF. These results demonstrate that G-PFE could be useful as a potential cosmetic ingredient for anti-wrinkle.
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KEYWORD
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Ponciri Fructus, Ganoderma lucidum, Collagen Biosynthesis, Matrix Metalloproteinase-1, Anti-wrinkle
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